to 'good up' karma you can also give money to the Church of Atom by talking to the reverend , to 'bad up' , i find stealing (whilst wearing a stealth boy,to avoid being found out too quick) is easiest , with hacking and lockpicking red safes/locks . for terminals , (ideally max out your science skill) look for stuff that lights up in between brackets , they're like bonuses that replenish your number of tries or take away a dud word , and just try over and over again. go to the Fallout Trophies page , you'll find info there regarding what quests cancels what.
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